Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial

Background We decided to conduct this study with the aim of investigating effects N-Acetylcysteine (NAC) on obesity complications and senescence visceral adipose tissue in obese adults. Methods analysis The present was conducted as a randomized clinical trial (RCT) (Clinical registry number: IRCT20220727055563N1) 40 adults candidates for bariatric surgery, who were randomly assigned receive 600 mg NAC ( n = 20) or placebo control 4 weeks. During used examine gene expression cells using SA-β-gal. Results Our findings showed that intervention significantly reduces SA-β-gal activity (as marker senescence) p16 interleukin 6 (IL-6) genes compared In addition, our potential beneficial effect administration reducing levels inflammatory factors including IL-6 high-sensitivity C-reactive protein (hs-CRP), well level fasting blood sugar (FBS), homeostatic model assessment insulin resistance (HOMA-IR), after adjusting confounders. No significant indicated anthropometric lipid profile. Conclusion Findings NAC, addition having some caused by obesity, seems have synolytic/senomorphic well. Clinical registration [ https://clinicaltrials.gov/ ], identifier [IRCT20220727055563N1].